Jeffrey L. Weiner

A mutation in the transmembrane domain of Adenylate cyclase 3 impairs enzymatic function to cause sex-specific depression- and anxiety-like behaviors and food seeking in a rat model

This study shows that a mutation in the transmembrane domain of Adcy3 in rats leads to sex-specific changes in adiposity, behavior, and cAMP production.

Triple network dynamics and future alcohol consumption in adolescents

This study uses brain network dynamics to predict future alcohol consumption in adolescents, finding sex-specific associations between network states and drinking behavior.

Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density

This study shows early life psychosocial stress increases binge ethanol consumption, and microglia inhibition reduces this effect and normalizes microglial population density.

Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus reduces appetitive and consummatory alcohol drinking behaviors

The paper investigates the role of the BLA-vHC circuit in alcohol drinking behaviors using chemogenetics and finds that inhibiting this pathway reduces appetitive drinking but not consummatory behaviors.

Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice

This study shows chronic ethanol exposure worsens Alzheimer's-like pathology, behavior, and metabolism in APP/PS1 mice by increasing amyloid plaques, altering brain metabolism, and affecting behavior.

Role of FMRP in rapid antidepressant effects and synapse regulation

This study shows that FMRP is required for the rapid antidepressant effects of Ro-25-6981 and that its regulation by mTORC1 and GABABR activity influences synapse formation and treatment outcomes in FXS models.

Chronic intermittent ethanol exposure selectively increases synaptic excitability in the ventral domain of the rat hippocampus

This study shows chronic intermittent ethanol exposure increases synaptic excitability specifically in the ventral hippocampus of rats, linked to changes in GluA2 and SK2 protein expression.