Reversible histone deacetylase activity catalyzes lysine acylation
Takeshi Tsusaka, Mohd Altaf Najar, Benjamin H. Schwarz, Eric Bohrnsen, Juan A. Osés-Prieto, Helena Neudorf, Christina Lee, Jonathan P. Little, Alma L. Burlingame, Catharine M. Bosio, George M. Burslem, Emily L. Goldberg
The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.
Nature Chemical Biology · Mar 26, 2025Peer-reviewedMolecular Biology