Author

Jonathan P. Little

University of British ColumbiaORCID 0000-0002-9796-2008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Emily L. GoldbergiD· 2 shared Helena NeudorfiD· 2 shared Alan Sheng-Hwa TungiD· 1 shared Alexandra P. SteeleiD· 1 shared Alma L. BurlingameiD· 1 shared Antonio Delgado‐GonzáleziD· 1 shared Anudari LetianiD· 1 shared Aurora Alvarez‐BuyllaiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMolecular Biology

Emily L. GoldbergORCID

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Author profile →

3 papers

Recent·Most cited

Insulin Prevents Fat Loss and Promotes Muscle Loss During Intermittent Fasting in Obesity

Daniel M. Marko, Meghan O. Conn, Joseph F. Cavallari, Helena Neudorf, Alexandra P. Steele, Brittany M. Duggan, Breanne T McAlpin, Nicole G. Barra, Thomas James Hawke, Jonathan P. Little, Jonathan D. Schertzer

This study shows that high insulin levels in obesity reduce fat loss and increase muscle loss during intermittent fasting.

bioRxiv · Jun 21, 2025 · PreprintPhysiology

Reversible histone deacetylase activity catalyzes lysine acylation

Takeshi Tsusaka, Mohd Altaf Najar, Benjamin H. Schwarz, Eric Bohrnsen, Juan A. Osés-Prieto, Helena Neudorf, Christina Lee, Jonathan P. Little, Alma L. Burlingame, Catharine M. Bosio, George M. Burslem, Emily L. Goldberg

The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.

Nature Chemical Biology · Mar 26, 2025Peer-reviewedMolecular Biology

A secondary β-hydroxybutyrate metabolic pathway linked to energy balance

María Dolores Moya-Garzón, Mengjie Wang, Veronica L. Li, Xuchao Lyu, Wei Wei, Alan Sheng-Hwa Tung, Steffen Henning Raun, Meng Zhao, Laëtitia Voilquin, Hashim Islam, Bárbara Oliveira, Yuqin Dai, Jan Spaas, Antonio Delgado‐González, Kenyi Donoso, , Jonathan Z. Long

This study identifies a secondary BHB metabolic pathway mediated by CNDP2, leading to BHB-amino acid metabolites that regulate energy balance in mice and humans.

Cell · Nov 12, 2024Peer-reviewedBiochemistry

Jonathan P. Little · henhao