George M. Burslem

This paper demonstrates the use of ubiquitin-derived diglycine remnants as chemical handles for chemoenzymatic proteomics, enabling antibody-independent analysis of protein ubiquitination.

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

The paper identifies and optimizes quinazolinone and phthalazinone inhibitors targeting the HDAC6 ZnF-UBD/ubiquitin interaction, using computational and experimental methods to improve their physicochemical properties and predict binding affinity.

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

This paper introduces a modular platform for rapidly evaluating PTM editing enzymes in living cells using induced proximity, demonstrating programmable acetylation of multiple substrates.

This study uses ABPP to show how MAPK pathway inhibitors alter kinase residue reactivity, reflecting conformational changes and resistance mechanisms in melanoma cells.

This study identifies TAOK2 as a kinase that regulates splicing and export of both viral and cellular transcripts by phosphorylating SRRM1/2, maintaining nuclear speckle structure and function.

The paper examines rRNA transcription and abundance in normal and leukemic hematopoiesis, finding cell-type-specific variations and functional roles in myeloid differentiation.

This paper introduces a protein editing technology that enables site-specific insertion of non-canonical residues into endogenous proteins in live mammalian cells.

The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.

This paper identifies class I HDACs as enzymes that catalyze lysine lactylation, showing that this modification is primarily formed through enzymatic action rather than non-enzymatic pathways.

The paper develops a new peptide-based inhibitor targeting caspase-8 and reveals shared specificities between inflammatory and apoptotic caspases.

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

The paper identifies an inhibitor of S-acyltransferase ZDHHC20 that suppresses Kras mutant lung tumor growth and improves survival.

The paper identifies acetylation at K228 as a regulator of PRMT1 degradation via FBXL17-mediated ubiquitination, independent of transcript levels.