Mohd Altaf Najar

Systems level phosphoproteomics reveals CAMKK2 driven kinase signaling underlying malignant phenotypes in gastric cancer

This study identifies CAMKK2 as a key driver of kinase signaling in gastric cancer through phosphoproteomic analysis, showing its role in promoting proliferation and malignant traits.

Systems-level proteomic reprogramming reveals mitochondrial restoration and inhibition of Rho GTPase-mediated cytoskeletal and inflammatory signaling in CKD

This study uses proteomic analysis to show DVA treatment restores mitochondrial function and suppresses inflammatory and oxidative stress pathways in CKD.

Temporal phosphoproteomics reveals rapid restoration of kinase signaling by Glycyrrhiza glabra in a rotenone-induced Parkinson disease model

This study uses temporal phosphoproteomics to show Glycyrrhiza glabra restores kinase signaling in a rotenone-induced Parkinson's model, identifying key pathways involved in neuroprotection.

Extraction-dependent bone proteomics reveals distinct stable and dynamic protein modules during early post-exposure degradation

This study evaluates bone protein extraction methods and identifies stable and dynamic protein modules during post-exposure degradation.

Integrated Metabolomic, Proteomic, and Phosphoproteomic Profiling Reveals CAMKK2-Dependent Regulation of Cell Cycle and Nucleotide Metabolism in Gastric Cancer

This study identifies CAMKK2 as a regulator of nucleotide metabolism and cell cycle in gastric cancer, showing its inhibition disrupts DNA replication and causes mitotic failure.

Phosphoproteomic profiling reveals signaling pathways modulated by Annona muricata leaf extract in oral adenosquamous carcinoma cells

This study uses phosphoproteomics to show that Annona muricata leaf extract inhibits oncogenic signaling in oral cancer cells by inducing hypophosphorylation of key pathways.

Serial enrichment based quantitative proteomics enables deep and multiplexed profiling of post-translational modifications

This paper introduces a serial enrichment workflow for quantitative proteomics that enables deep and multiplexed profiling of multiple post-translational modifications from a single sample.

Coordination of nuclear RNA processing by speckle-localized kinase TAOK2

This study identifies TAOK2 as a kinase that regulates splicing and export of both viral and cellular transcripts by phosphorylating SRRM1/2, maintaining nuclear speckle structure and function.

Intracellular Protein Editing to Enable Incorporation of Non-Canonical Residues into Endogenous Proteins

This paper introduces a protein editing technology that enables site-specific insertion of non-canonical residues into endogenous proteins in live mammalian cells.

Reversible histone deacetylase activity catalyzes lysine acylation

The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.

Class I histone deacetylases catalyze lysine lactylation

This paper identifies class I HDACs as enzymes that catalyze lysine lactylation, showing that this modification is primarily formed through enzymatic action rather than non-enzymatic pathways.

Opposing roles of p38α phosphorylation and arginine methylation in driving TDP-43 proteinopathy.

This study identifies opposing roles of p38α phosphorylation and arginine methylation in TDP-43 proteinopathy, showing that phosphorylation promotes aggregation while methylation reduces it.

The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

The paper identifies acetylation at K228 as a regulator of PRMT1 degradation via FBXL17-mediated ubiquitination, independent of transcript levels.