LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay
Anna Mattout, Dimos Gaidatzis, Jan Padeken, Christoph D. Schmid, Florian Aeschimann, Véronique Kalck, Susan M. Gasser
The paper identifies a pathway in C. elegans where LSM2-8 and XRN-2 selectively degrade H3K27me3-marked genes, revealing a new layer of heterochromatin regulation in animals.
Nature Cell Biology · Apr 6, 2020Peer-reviewedMolecular Biology