Bioactive Enhanced Adjuvant Chemokine Oligonucleotide Nanoparticles (BEACON) for Mucosal Vaccination Against Genital Herpes
Sachin H. Bhagchandani, Stephen A. Ehrenzeller, Ivan Susin Pires, Namit Chaudhary, Carmen Jane Booth, Dong-il Kwon, Charalampia Koutsioumpa, Christopher A. Baker, Claire Laxton, Keyla Santos Guedes de Sá, Cullen Matthews, Priya Gill, Sarah Li, Anna Olszowka, Andrew Hudak, , Akiko Iwasaki
This paper develops BEACON, a mucosal adjuvant that enhances protective immunity against HSV-2 in mice by increasing CD8+ TRM populations and mucosal antibody responses.
Science Immunology · Jun 19, 2026Peer-reviewedImmunology