Christopher A. Baker

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

Distribution and strength of interlaminar synaptic connectivity in mouse primary visual cortex revealed by two-photon optogenetic stimulation

The paper measures synaptic inputs onto superficial excitatory neurons in mouse primary visual cortex using two-photon optogenetic stimulation and finds that layer 4 excitatory neurons and somatostatin-neurons in layer 2/3 are the most common sources of input, with strong connections distributed across cells.

Multimodal cell type correspondence by intersectional mFISH in intact tissues

The paper presents a method combining spatial transcriptomics with optogenetic mapping to resolve cell type characteristics in mouse cortex.

Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

The paper examines sparse excitatory connectivity in adult mouse and human cortex using electrophysiology and optogenetics, finding sparse connections and synaptic dynamics across layers.

A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality

The paper introduces a new set of transgenic mouse lines for precise targeting and manipulation of brain cell types, enhancing genetic tools for neuroscience research.