SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids
Elpida Statoulla, Maria Zafeiri, Kleanthi Chalkiadaki, Georgia Voudouri, Karmel Sofia Gkika, Christos Papazoglou, Thomas M. Durcan, Arkady Khoutorsky, Seyed Mehdi Jafarnejad, Sarah Maguire, Alexander E. Dityatev, Christos G. Gkogkas
This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.
npj Parkinson s Disease · Feb 16, 2026Peer-reviewedNeuroscience