Arkady Khoutorsky

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.

This study shows that 4E-BP2 controls specific mRNA translation in GABAergic interneurons, which is necessary for long-term memory formation.

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

This study shows that microglia prune astrocytic processes in response to high-salt diet, leading to increased neuronal activity and hypertension.

This study shows that gut microbiota from fibromyalgia patients causes pain in mice, and transferring healthy microbiota alleviates symptoms in humans.

This study uses single-cell RNA sequencing to analyze spinal cord microglia responses to nerve injury, identifying sex- and time-specific changes and a role for ApoE in neuropathic pain.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.