Sarah Maguire

Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

GIGYF2/4EHP-Mediated Translational Attenuation Maintains Cellular Homeostasis Following Ionizing Radiation

This study shows that GIGYF2/4EHP-mediated translational repression helps maintain cellular homeostasis after ionizing radiation by preserving proteostasis and cell viability.

Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

Mutant KRAS dosage contributes to heterogeneity in lung cancer therapeutic response

This study shows that mutant KRAS dosage affects therapeutic response in lung cancer, with higher dosages linked to resistance to platinum therapy and sensitivity to pS6K inhibition.

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.