Seyed Mehdi Jafarnejad

This study shows that GIGYF2/4EHP-mediated translational repression helps maintain cellular homeostasis after ionizing radiation by preserving proteostasis and cell viability.

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.

This study shows that eIF5B is crucial for OSCC cell survival by enabling non-canonical translation of pro-survival mRNAs, and its inhibition reduces tumor growth and sensitizes cells to apoptosis.

The paper shows that human GIGYF2 does not interact with GRB10, challenging the current understanding of their role in disease.

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

This study shows that p38γ and p38δ regulate innate immune responses by modulating MEF2D phosphorylation and transcriptional activity in mice.

The paper identifies mRNA sequences that stall ribosomes in neurons, linking these sequences to FMRP association and stalled polysome function.

The paper identifies an alternative 5' leader in Inpp5e mRNA that enhances translation and confers resistance to oncolytic virus infection in cancer cells.