Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis and iron homeostasis
Judith Giroud‐Gerbetant, Fernando Sotillo, Gonzalo Hernández, Cian J Lynch, Irene Ruano, Barbara Siri, David Sebastián, António Zorzano, Rafael Artuch, Aída Ormazábal, Mayka Sánchez, Günter Weiß, Neus Prats, Carlo Dionisi‐Vici, Manuel Serrano, , Susanna Bodoy
This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.
bioRxiv · Aug 15, 2021 · PreprintMolecular Biology