Irene Ruano

This study identifies MET signaling as a targetable vulnerability in rhabdoid tumors through integrated single-cell multi-omic and spatial transcriptomics analyses.

This paper identifies and categorizes technical biases in imaging spatial transcriptomics and proposes a unified framework to model these biases.

The paper develops spFBA to analyze spatial metabolic differences in cancer, revealing metastatic mimicking and lactate-consuming cells in colorectal tumors.

The paper uses spatial molecular imaging data to map human tonsil architecture and provides an analytical framework for Spatial Immunology.

This paper adapts copy number variation inference to image-based spatial transcriptomics data to map malignant clones and tumor microenvironment at single-cell resolution.

This paper traces colorectal cancer progression by integrating spatial transcriptomics, single-nucleus RNA-sequencing, and histopathology to map cellular and molecular changes across tumor stages.

The paper uses single-cell sequencing and spatial transcriptomics to compare immune responses in leptomeningeal disease with other CNS disorders, identifying disease-specific immune environments and progression mechanisms.

This paper describes the development of HYL001, a TGFβ inhibitor that effectively combats microsatellite stable CRC metastasis in mice when combined with immune checkpoint therapy.

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.