David Sebastián

Pdk1-dependent metabolic heterogeneity promotes aggressive colorectal cancer through cell-intrinsic interferon signaling

This study identifies Pdk1-high metabolic cancer cells in colorectal tumors that drive aggressive behavior through interferon signaling.

Fasting-induced hepatic gluconeogenesis is compromised in Anxa6-/- mice

This study shows that Anxa6-/- mice have impaired fasting-induced hepatic gluconeogenesis, leading to hypoglycaemia and reliance on lipid oxidation.

Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis and iron homeostasis

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.

Impairment of neuronal mitophagy by mutant huntingtin

This study shows mutant huntingtin impairs neuronal mitophagy by disrupting key protein interactions and complexes, leading to mitochondrial dysfunction and neurodegeneration in Huntington's disease.

A Comprehensive Reanalysis Of Publicly Available GWAS Datasets Reveals An X Chromosome Rare Regulatory Variant Associated With High Risk For Type 2 Diabetes.

The paper reanalyzes T2D GWAS data to identify a rare X chromosome variant associated with increased T2D risk in males.