Author

Claire Bryant

Yale UniversityPrimary ORCID profile (0000-0002-4609-372X · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Claire BryantiD3 papers · Nationwide Children's Hospital

Biology Disciplines

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Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:diffusion model· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:multiple species· 1

Frequent Co-Authors

Assaf AloniD· 2 shared Brandon Lam· 2 shared Chao YangiD· 2 shared Jiankun LyuiD· 2 shared Aakash DavasamiD· 1 shared Chia‐Hsueh LeeiD· 1 shared Dmytro S. RadchenkoiD· 1 shared Dylan Barcelos· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

Assaf AlonORCID

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2 papers

Recent·Most cited

AlphaFold3 for Structure-guided Ligand Discovery

Kartikeya M. Menon, Aakash Davasam, Guo Chen, Claire Bryant, Zifang Deng, Brandon Lam, Chao Yang, Dylan Barcelos, Fangyu Liu, Assaf Alon, Jiankun Lyu

Retrospective and prospective benchmarks show AlphaFold3 co-folding memorizes training poses and achieves half the prospective hit rate of DOCK3 at 6,700-fold higher cost, but excels as a post-docking filter.

bioRxiv · Jun 12, 2026 · PreprintPharmacology & Toxicology✦ In-depth digest

Combinatorial docking and molecular generation to navigate over 100-billion molecules for prospective ligand discovery

Jianxiang Zhang, Chao Yang, Yu Zhang, Xiao Chen, Brandon Lam, Claire Bryant, Shabareesh Pidathala, Yangzhi Wang, Yurii Moroz, Dmytro S. Radchenko, Assaf Alon, Chia‐Hsueh Lee, Zhe Zhang, Jiankun Lyu

The paper introduces CombiDOCK and MINT-Dock to efficiently screen large molecule libraries for ligand discovery, achieving high hit rates and computational efficiency.

bioRxiv · Jun 11, 2026 · PreprintBioinformatics