Kartikeya M. Menon

In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.

Retrospective and prospective benchmarks show AlphaFold3 co-folding memorizes training poses and achieves half the prospective hit rate of DOCK3 at 6,700-fold higher cost, but excels as a post-docking filter.

The paper introduces a single vesicle fluorescence microscopy platform to quantify phospholipid scrambling by VDAC1 dimers and opsin, revealing kinetic heterogeneity in scrambling rates.