H2A.Z levels control the timing of major events at the maternal-zygotic transition
Pakinee Phromsiri, Xiaolu Wei, Claire E. Makowski, Noah J. Reger, Duy K. Nguyen, Humaira Marzia Alam, Yuki Shindo, Amanda A. Amodeo, Patrick J. Murphy, Fanju W. Meng, Michael Andreas Welte
This study shows that H2A.Z levels act as a timer for the maternal-zygotic transition in Drosophila and zebrafish, influencing developmental timing through both nuclear and non-nuclear mechanisms.
bioRxiv · May 4, 2026 · PreprintDevelopmental Biology