Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
Khaldoun Gharzeddine, Cristina Gonzalez Prieto, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo‐Botté, Cyrille Y. Botté, Fabienne Thomas, Marie‐Hélène Laverrière, Édouard Girard, Gaël S. Roth, Arnaud Millet
This study shows that blocking CSF-1R in tumor-associated macrophages alters their metabolism, enhancing sensitivity to 5-fluorouracil in colorectal cancer.
Journal for ImmunoTherapy of Cancer · Sep 1, 2024Peer-reviewedImmunology