A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates
Victoria E. Deneke, Andreas Blaha, Yonggang Lu, Johannes P Suwita, Jonne M. Draper, Clara S. Phan, Karin Panser, Alexander Schleiffer, Laurine Jacob, Theresa Humer, Karel Stejskal, Gabriela Krššáková, Elisabeth Roitinger, Dominik Handler, Maki Kamoshita, , Andrea Pauli
The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.
Cell · Oct 17, 2024Peer-reviewedDevelopmental Biology