Author

Andreas Blaha

University of ViennaORCID 0000-0002-0995-4228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrea PauliiD· 5 shared Karin PanseriD· 4 shared Masahito IkawaiD· 4 shared Victoria E. DenekeiD· 3 shared Yonggang LuiD· 3 shared Alexander SchleifferiD· 2 shared Elisabeth RoitingeriD· 2 shared Gabriela Krššáková· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersDevelopmental Biology

Andrea PauliORCID

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5 papers

Recent·Most cited

The SPARK complex forms the molecular basis of vertebrate fertilization

Victoria E. Deneke, Johannes P Suwita, Haoting Wang, Shingo Tonai, Yonggang Lu, Karin Panser, Alexander Schleiffer, Jeremy A. Hollis, Maria Novatchkova, Gerhard Duernberger, Karel Stejskal, Gabriela Krššáková, Andreas Blaha, Aleq Adrianne R. Andresan, Muriel Mirus, , Andrea Pauli

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

bioRxiv · May 15, 2026 · PreprintDevelopmental Biology

Bouncer's receptor on sperm: Investigating sperm-egg compatibility in fish

Andreas Blaha, Andrea Pauli

The paper tests cross-species sperm-egg compatibility in fish by swapping Spaca6 and Izumo1 proteins between medaka and zebrafish, showing that specific molecular interactions are required for fertilization.

bioRxiv · Dec 13, 2024 · PreprintDevelopmental Biology

A conserved fertilization complex of Izumo1, Spaca6, and Tmem81 mediates sperm-egg interaction in vertebrates

Victoria E. Deneke, Andreas Blaha, Yonggang Lu, Johannes P Suwita, Jonne M. Draper, Clara S. Phan, Karin Panser, Alexander Schleiffer, Laurine Jacob, Theresa Humer, Karel Stejskal, Gabriela Krššáková, Elisabeth Roitinger, Dominik Handler, Maki Kamoshita, , Andrea Pauli

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

Cell · Oct 17, 2024Peer-reviewedDevelopmental Biology

Sperm membrane proteins DCST1 and DCST2 are required for the sperm-egg fusion process in mice and fish

Taichi Noda, Andreas Blaha, Yoshitaka Fujihara, Krista R. Gert, Chihiro Emori, Victoria E. Deneke, Seiya Oura, Karin Panser, Yonggang Lu, Sara Berent, Mayo Kodani, Luis Enrique Cabrera-Quio, Andrea Pauli, Masahito Ikawa

This study shows that DCST1 and DCST2 are essential for sperm-egg fusion in mice and zebrafish, with mutations leading to male infertility.

Communications Biology · Apr 7, 2022Peer-reviewedDevelopmental Biology

The sperm protein SPACA4 is required for efficient fertilization in mice

Yoshitaka Fujihara, Sarah Herberg, Andreas Blaha, Karin Panser, Kiyonori Kobayashi, Tamara Larasati, Maria Novatchkova, Hans‐Christian Theussl, Olga Olszanska, Masahito Ikawa, Andrea Pauli

This study identifies SPACA4 as an essential sperm protein required for zona pellucida penetration during mammalian fertilization in mice.

Proceedings of the National Academy of Sciences · Sep 23, 2021Peer-reviewedDevelopmental Biology