Yonggang Lu

This paper introduces a cuffed guide RNA (cgRNA) that enables miRNA activity-dependent genome editing in human and mouse cells.

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

This study identifies FIMP as a binding partner of TMEM95, determines their complex structure, and shows that disrupting this interaction inhibits sperm-egg fusion.

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

This study shows human TMEM95 binds eggs, identifies a binding region via crystallography, and develops antibodies that impair sperm-egg fusion without blocking binding.

This study identifies 1700029I15Rik as a gene critical for the biosynthesis of acrosomal membrane proteins necessary for sperm-egg fusion in mice.

This study shows that DCST1 and DCST2 are essential for sperm-egg fusion in mice and zebrafish, with mutations leading to male infertility.

The paper shows that sperm cooperation in mice forms clusters at the utero-tubal junction, facilitating oviduct entry and fertilization, with defects in this process linked to infertility.