CAR-T Targeting of Mutant Calreticulin Establishes a Potentially Curative Stem Cell-Directed Therapy for Myeloproliferative Neoplasms
Daniel C. Choi, Giovanni Medico, Irina V. Lebedeva, Elisabeth K. Nyakatura, Clarisse Kayembe, Franco Castillo Tokumori, Pouneh Kermani, Nassima Messali, Olivia Vergnolle, Abigail Taylor, Maria Mia Yabut, Urko del Castillo, Paul J. Balderes, Manuel Baca, Giorgio Inghirami, Joseph Michael Scandura
This study demonstrates that CAR-T cells targeting mutant calreticulin can eliminate MPN-propagating HSCs in xenograft models without antigen escape.
bioRxiv · Feb 11, 2026 · PreprintCancer Biology