Claudia Goupil

In vivo dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1

The paper uses CRISPR-Cas9 in mice to identify modifier genes that affect the severity of tyrosinemia type 1 by editing enzymes in the tyrosine catabolic pathway.

Marker-free coselection for successive rounds of prime editing in human cells

This paper introduces a coselection strategy for prime editing in human cells using the Na+/K+ ATPase to enable efficient multiallelic editing and reduce the need for pegRNA optimization.