Author

A Loiselle

Centre hospitalier de l'Université Laval

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Alexis DuringeriD· 1 shared Behnaz NateghiiD· 1 shared Calon Frédéric· 1 shared Chantelle F. SephtoniD· 1 shared Claudia Goupil· 1 shared Cyntia TremblayiD· 1 shared Daniel AgudeloiD· 1 shared David A. A BennettiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMolecular Biology

Alexis DuringerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Higher Angiotensin I Converting Enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease.

Louise Réveret, Leclerc Manon, Emond Vincent, A Loiselle, Philippe Bourassa, Cyntia Tremblay, David A. A Bennett, Hébert Sébastien, Calon Frédéric

This study finds higher ACE2 levels in the brains of Alzheimer's patients, which may increase CNS SARS-CoV-2 infection risk.

bioRxiv · Jan 17, 2023 · PreprintNeuroscience

Marker-free coselection for successive rounds of prime editing in human cells

Sébastien Levesque, Diana Mayorga, Jean-Philippe Fiset, Claudia Goupil, Alexis Duringer, A Loiselle, Eva Bouchard, Daniel Agudelo, Yannick Doyon

This paper introduces a coselection strategy for prime editing in human cells using the Na+/K+ ATPase to enable efficient multiallelic editing and reduce the need for pegRNA optimization.

Nature Communications · Oct 7, 2022Peer-reviewedMolecular Biology

Widespread alterations in microRNA biogenesis in human Huntington's disease putamen

Séréna Petry, Rémi Keraudren, Behnaz Nateghi, A Loiselle, Karolina Pircs, Johan Jakobsson, Chantelle F. Sephton, Mélanie Langlois, Isabelle St‐Amour, Sébastien S. Hébert

This study investigates miRNA biogenesis defects in HD brain tissue, finding downregulation of key enzymes and maturation defects, primarily in the striatum.

Acta Neuropathologica Communications · Jul 22, 2022Peer-reviewedNeuroscience