Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Maarten C. Hardenberg, Tessa Sinnige, Sam Casford, Samuel Toluwanimi Dada, Chetan Poudel, Elizabeth A. Robinson, Mónika Fuxreiter, Clemens Kaminksi, Gabriele S. Kaminski Schierle, Ellen A. A. Nollen, Christopher Martin Dobson, Michele Vendruscolo
The paper shows that α-synuclein forms liquid droplets that mature into amyloid-rich hydrogels, suggesting Lewy body formation is linked to arrested maturation in the presence of lipids.
Journal of Molecular Cell Biology · Dec 12, 2020Peer-reviewedMolecular Biology