Chetan Poudel

A Human Precision Cut Kidney Slice Platform for Studying Glomerular Biology and Therapeutic Responses

This study uses human precision cut kidney slices to analyze gene expression responses to culture conditions and IFNγ stimulation, showing reproducible APOL1 expression changes.

High-throughput, organ-scale 3D tubule tracking using TubuleMAP

The paper introduces TubuleMAP, a semi-automated 3D tubule tracking pipeline for analyzing tubular networks, achieving high throughput and accuracy in reconstructing kidney and testis tubules.

Nanoscale Optical Imaging, Reconstruction, and Spatial Analysis of Whole Mouse Glomeruli

The paper develops a pipeline for high-resolution imaging and analysis of whole mouse glomeruli, revealing novel aging and disease-related phenotypes.

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells

This study shows that satellite repeat transcripts in mouse ESCs drive heterochromatin condensates, which are crucial for chromosome stability and nuclear organization.

A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors

The paper develops a unified in vitro to in vivo fluorescence lifetime screening platform to identify amyloid β aggregation inhibitors, revealing a new compound effective in multiple models.

Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

The paper shows that α-synuclein forms liquid droplets that mature into amyloid-rich hydrogels, suggesting Lewy body formation is linked to arrested maturation in the presence of lipids.