Tessa Sinnige

Polyglutamine aggregation in the C. elegans nervous system is driven by stochastic nucleation events

This study shows polyglutamine aggregation in C. elegans neurons occurs through stochastic nucleation, independent of cellular context and ageing.

Human tau compromises neuronal structural integrity in C. elegans promoted by age, stress and phosphorylation

This study shows human tau disrupts neuronal structure in C. elegans, with effects worsened by age, stress, and phosphorylation.

Urolithin B reduces the aggregate load of islet amyloid polypeptide in Caenorhabditis elegans

This study shows urolithin B reduces insoluble IAPP-GFP levels in C. elegans without affecting mitochondrial association, suggesting a potential therapeutic strategy for T2DM.

Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

The paper shows that α-synuclein forms liquid droplets that mature into amyloid-rich hydrogels, suggesting Lewy body formation is linked to arrested maturation in the presence of lipids.