Uncoordinated long-patch base excision repair at juxtaposed DNA lesions generates a lethal accumulation of double-strand breaks
Kenji Shimada, Barbara van Loon, Christian‐Benedikt Gerhold, Stephanie Bregenhorn, Verena Hurst, Grégory Roth, Cleo V D Tarashev, Christian Heinis, Josef Jiricny, Susan M. Gasser
The paper shows that uncoordinated BER activity at DNA lesions causes DSB accumulation in yeast exposed to Zeocin, leading to genomic fragmentation.
bioRxiv · Nov 15, 2020 · PreprintMolecular Biology