Molecular BiologybioRxivPreprint
Uncoordinated long-patch base excision repair at juxtaposed DNA lesions generates a lethal accumulation of double-strand breaks
Kenji Shimada, Barbara van Loon, Christian‐Benedikt Gerhold…·Susan M. Gasser
The paper shows that uncoordinated BER activity at DNA lesions causes DSB accumulation in yeast exposed to Zeocin, leading to genomic fragmentation.
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