Axon guidance pathways modulate neurotoxicity of ALS-associated UBQLN2
Sang Hwa Kim, Kye D Nichols, Eric Nathaniel Anderson, Yining Liu, Nandini Ramesh, Weiyan Jia, Connor J Kuerbis, Mark Scalf, Lloyd M. Smith, Udai Bhan Pandey, Randal S. Tibbetts
This study identifies axon guidance pathways as modulators of UBQLN2 toxicity in ALS/FTD, showing reduced neurodegeneration with UNC5B and DCC suppression in multiple models.
eLife · Apr 11, 2023Peer-reviewedNeuroscience