Fully Modified SpyCas9 Guide RNAs Enable Robust Genome Editing In Cells and In Vivo
Kim Anh Vu, Han Zhang, Nadia Amrani, Gitali Devi, Nicholas Gaston, Jonathan Lee, Stacy A. Maitland, Zexiang Chen, Dimas Echeverria, Pengpeng Liu, Karthikeyan Ponnienselvan, Matthew B. Hanlon, Connor Lucas, Kevin Luk, Jacquelyn Sousa, , Jonathan K. Watts
The paper develops fully modified SpyCas9 guide RNAs that maintain or enhance genome editing efficacy in vitro and in vivo.
bioRxiv · May 28, 2026 · PreprintBiochemistry