Author

Nicholas Gaston

University of Massachusetts Chan Medical SchoolORCID 0000-0002-3862-9002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 3 shared David CooperiD· 3 shared Dimas EcheverriaiD· 3 shared Erik J. SontheimeriD· 3 shared Han ZhangiD· 3 shared Jonathan K. WattsiD· 3 shared Guangping GaoiD· 2 shared Jonathan LeeiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Anastasia KhvorovaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntingtons disease

Jillian Belgrad, Todd M. Greco, Ellen Sapp, Ashley Summers, Daniel O’Reilly, Eric Luu, Josiah E. Hutton, Nozomi Yamada, Hassan H. Fakih, Raymond C. Furgal, Dimas Echeverria, Nicholas McHugh, Brianna M. Bramato, Chantal Ferguson, Samuel R. Hildebrand, , Anastasia Khvorova

The paper uses RNAi to identify dose-dependent MMR gene modulators of somatic instability and proteome changes in HD mouse models.

bioRxiv · Jun 25, 2026 · PreprintNeuroscience

Fully Modified SpyCas9 Guide RNAs Enable Robust Genome Editing In Cells and In Vivo

Kim Anh Vu, Han Zhang, Nadia Amrani, Gitali Devi, Nicholas Gaston, Jonathan Lee, Stacy A. Maitland, Zexiang Chen, Dimas Echeverria, Pengpeng Liu, Karthikeyan Ponnienselvan, Matthew B. Hanlon, Connor Lucas, Kevin Luk, Jacquelyn Sousa, , Jonathan K. Watts

The paper develops fully modified SpyCas9 guide RNAs that maintain or enhance genome editing efficacy in vitro and in vivo.

bioRxiv · May 28, 2026 · PreprintBiochemistry

Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope

Nathan Bamidele, Han Zhang, Xiaolong Dong, Nicholas Gaston, Haoyang Cheng, Karen L. Kelly, Jonathan K. Watts, Jun Xie, Guangping Gao, Erik J. Sontheimer

This paper engineers Nme2Cas9 base editors to improve activity and targeting scope, enabling correction of MECP2 mutations with minimal off-target effects.

bioRxiv · Apr 14, 2023 · PreprintMolecular Biology

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo

Han Zhang, Karen L. Kelly, Jonathan Lee, Dimas Echeverria, David Cooper, Rebecca Panwala, Zexiang Chen, Nicholas Gaston, Gregory A. Newby, Jun Xie, David R. Liu, Guangping Gao, Scot A. Wolfe, Anastasia Khvorova, Jonathan K. Watts, Erik J. Sontheimer

This study demonstrates the use of protecting oligos to enhance crRNA stability and potency for in vivo genome editing via AAV co-delivery in mice.

bioRxiv · Mar 20, 2023 · PreprintMolecular Biology