Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV
Leila B. Giron, Maliha W. Shaikh, Thaisa M. Cantu-Jungles, Lijuan Zhang, Phillip A. Engen, Nuseybe Bulut, S Shyamkishor Singh, Jenna M. Hasson, Ellen Zhang, Shivanjali Shankaran, Corey Neumann, Michelle Villanueva, ALAN L. LANDAY, Thomas J. Hope, Frank Joseph Palella, , Mohamed Abdel‐Mohsen
This study identifies loss of intestinal 1,2-fucose in HIV-treated individuals as a modifiable host-microbiome mechanism linked to inflammation, barrier dysfunction, and aging.
bioRxiv · Jul 10, 2026 · PreprintMicrobiology