Phillip A. Engen

Seed Amplification Assay-Based Detection of Alpha-Synuclein Aggregates Outperforms Immunohistochemical Analysis in the Intestinal Mucosal Biopsies of Parkinson's Disease and Multiple System Atrophy Participants

This study compares a seed amplification assay for alpha-synuclein aggregates with immunohistochemistry in intestinal biopsies of Parkinson's disease and multiple system atrophy patients, finding the assay detects aggregates more frequently and with higher specificity.

Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV

This study identifies loss of intestinal 1,2-fucose in HIV-treated individuals as a modifiable host-microbiome mechanism linked to inflammation, barrier dysfunction, and aging.

Sexually dimorphic responses to MPTP found in microglia, inflammation and gut microbiota in a progressive monkey model of Parkinson's disease

This study investigates sex differences in inflammatory responses and gut microbiota in a progressive monkey model of Parkinson's disease following MPTP treatment.