Author

Frank Joseph Palella

Northwestern UniversityORCID 0000-0002-2277-6841Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Hiroaki TatenoiD· 2 shared Leila B. GironiD· 2 shared Michael J. CorleyiD· 2 shared Mohamed Abdel‐MohseniD· 2 shared ALAN L. LANDAYiD· 1 shared Alejandra BorjabadiD· 1 shared Ali KeshavarzianiD· 1 shared Anthony J. SecretoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

Hiroaki TatenoORCID

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2 papers

Recent·Most cited

Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV

Leila B. Giron, Maliha W. Shaikh, Thaisa M. Cantu-Jungles, Lijuan Zhang, Phillip A. Engen, Nuseybe Bulut, S Shyamkishor Singh, Jenna M. Hasson, Ellen Zhang, Shivanjali Shankaran, Corey Neumann, Michelle Villanueva, ALAN L. LANDAY, Thomas J. Hope, Frank Joseph Palella, , Mohamed Abdel‐Mohsen

This study identifies loss of intestinal 1,2-fucose in HIV-treated individuals as a modifiable host-microbiome mechanism linked to inflammation, barrier dysfunction, and aging.

bioRxiv · Jul 10, 2026 · PreprintMicrobiology

Inhibiting Glycan Degradation Prevents HIV-Induced Inflammaging and Cognitive Impairment

Leila B. Giron, Alejandra Borjabad, Eran Hadas, Janeway Granche, Erika G. Marques de Menezes, Thomas A. Premeaux, Hongxia He, Stephen T. Yeung, Shalini Thakur Singh, Courtney Friday, Joshua A. Glover, Eric Balboa, Derrick L. Dopkin, Michelle Burrows, Anthony J. Secreto, , Mohamed Abdel‐Mohsen

This study shows that inhibiting glycan degradation prevents HIV-induced inflammation, aging, and cognitive impairment in animal models and human cohorts.

Med · Jun 5, 2026Peer-reviewedMicrobiology