Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism
Conor J. Crawford, Charles W.E. Tomlinson, Christian Gunawan, Zongjia Chen, Dominic P. Byrne, Cosette Darby, Martina Conti, Tony R. Larson, Ana Sofia Luis, Stefano Elli, Edwin Alexander Yates, David N. Bolam, Sjoerd van der Post, Spencer John Williams, Alan Cartmell
The paper shows arylsulfamates inhibit Bacteroides growth on sulfated glycans via a lipid kinase, not carbohydrate sulfatases, and identifies resistance mechanisms.
Proceedings of the National Academy of Sciences · Jul 10, 2025Peer-reviewedBiochemistry