Sjoerd van der Post

Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin

The paper shows ETEC protease EatA degrades human MUC2 mucin specifically, enabling bacterial infection by disrupting the intestinal mucus layer.

Cryo-EM structure of CLCA1 identifies CLCA1 as a founding member of a novel metzincin family.

The paper determines the Cryo-EM structure of CLCA1, revealing its unique domain organization and regulatory mechanisms, and identifies it as a founding member of a new metzincin family.

The role of Akkermansia muciniphila sulfatases in colonic mucinutilisation

This study investigates the role of Akkermansia muciniphila sulfatases in colonic mucin utilization, revealing unique adaptations compared to Bacteroides species.

Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism

The paper shows arylsulfamates inhibit Bacteroides growth on sulfated glycans via a lipid kinase, not carbohydrate sulfatases, and identifies resistance mechanisms.

BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection

This study identifies BPP43_05035 as a Brachyspira pilosicoli adhesin that disrupts epithelial tight junctions, increasing barrier permeability during infection.

ProteoSushi: a software tool to biologically annotate and quantify modification-specific, peptide-centric proteomics datasets

ProteoSushi is a software tool designed to annotate and quantify modification-specific proteomics datasets by prioritizing peptide-centric analysis and integrating biological information.

ProteoClade: a taxonomic toolkit for multi-species and metaproteomic analysis

ProteoClade processes multi-species proteomic data for taxa-specific analysis and quantitation, enabling efficient workflows for complex microbiota samples.