Combination of enhanced gene activation and cell death causes lethal inflammatory pulmonary fibrosis
Julia Saggau, Christine Kiefer, Debora Bonasera, Luisa Schmidt, Louisa Grauvogel, Paulina Engel, Santiago Serrano Sáenz, Craig Thrussell, Hassan Rakhsh-Khorshid, Konstantinos Kelepouras, Zsolt Megyesfalvi, Balázs Döme, Marcus Krüger, Antonella Montinaro, Nima Abedpour, , Henning Walczak
The paper shows that enhanced gene activation in specific LUBAC mutants leads to cell death and lethal lung fibrosis, revealing gene activation as a root cause of inflammatory disease.
bioRxiv · Sep 7, 2026 · PreprintCell Biology