Henning Walczak

Combination of enhanced gene activation and cell death causes lethal inflammatory pulmonary fibrosis

The paper shows that enhanced gene activation in specific LUBAC mutants leads to cell death and lethal lung fibrosis, revealing gene activation as a root cause of inflammatory disease.

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

This study identifies dysregulated epithelial cell death signaling in inflammatory bowel disease, showing it persists during remission despite therapy.