Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium
Arantxa Cebrián‐Silla, Fiona Dale-Huang, Stephanie Redmond, Carmen Elena Aragon Ortiz, Juan Moriano, Marcos Assis Nascimento, Zhenmeiyu Li, Cristina D. Guinto, Susana González-Granero, Ricardo Romero-Rodriguez, Cathryn René Cadwell, Vicente Herranz‐Pérez, José Manuel García‐Verdugo, Arnold R. Kriegstein, Eric Jinsheng Huang, Arturo Álvarez-Buylla
The paper identifies a novel ependymal cell type (E2) in the forebrain that senses cerebrospinal fluid signals via specialized cilia and Smoothened receptor.
bioRxiv · Aug 11, 2026 · PreprintCell Biology