Cathryn René Cadwell

The paper identifies a novel ependymal cell type (E2) in the forebrain that senses cerebrospinal fluid signals via specialized cilia and Smoothened receptor.

AEGIS identifies epitope- and clone-specific autoimmunity in ROHHAD by linking immune repertoires to self-epitopes, revealing convergence on ZSCAN1 epitopes in the CNS.

The paper maps retinal ganglion cell functional diversity in the mouse superior colliculus and identifies specialized response types for collision detection.

The paper introduces a method to map neuronal circuits using barcoded rabies virus and single-nucleus RNA sequencing, revealing cell-type-specific circuit motifs in developing human cerebral cortex.

The paper uses snRNA-seq to analyze mosaic chromosome 1q gain in a case of epilepsy with hyaline protoplasmic astrocytopathy, finding cell-type-specific gene expression changes in neurons and astrocytes.

The paper combines morpho-electric and transcriptomic data from mouse motor cortex neurons to show that transcriptomic types within families form continuous morpho-electric landscapes rather than discrete entities.

The paper characterizes cell types and circuit organization within neocortical radial clones using single-cell RNA-sequencing and electrophysiological recordings, finding that clones contain diverse cell types and exhibit specific connectivity patterns.

The paper identifies distinct cell types and circuit organization in layer 4 of primary sensory areas in adult mouse neocortex, challenging the canonical microcircuit model.