José Manuel García‐Verdugo

Cerebral organoids recapitulate interneuron chain migration in the human cortex

This study shows that long-term human cerebral organoids replicate postnatal interneuron migration, revealing chain migration and genetic factors linked to neurodevelopmental disorders.

Intracranial Targeting of Cholesterol Processing Reveals a Therapeutic Vulnerability that Reprograms Glioblastoma and Promotes Antitumor Immunity

This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.

Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

The paper identifies a novel ependymal cell type (E2) in the forebrain that senses cerebrospinal fluid signals via specialized cilia and Smoothened receptor.

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus

This study maps the spatial and molecular changes in neural progenitor cells in the human dentate gyrus from gestation to postnatal stages, showing a decline in neurogenic potential and transition to astrocytic features.

Metabolic and transcriptional adaptations to phagocytosis in microglia sustain their functionality and regenerative properties

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

Cerebral Organoids Uncover Mechanisms of Neural Activity Changes in Epileptogenesis

This paper uses cerebral organoids to model Tuberous Sclerosis Complex and identifies mechanisms of neural activity changes in epileptogenesis, showing potential for drug testing.

Unveiling the neuro-vascular interplay in the skeletal muscle in health, injury and disease

The paper identifies kranocytes as sensory platforms in neuromuscular junctions that connect adjacent junctions, interact with microvasculature, and respond to injury or disease.

Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone

This study identifies B2 cells as the primary neural stem cells in the adult mouse V-SVZ, replacing B1 cells postnatally to sustain neurogenesis.

Anatomy, histology and ultrastructure of the adult human olfactory peduncle: blood vessel and corpora amylacea assessment

This study examines the anatomy, histology, and ultrastructure of the human olfactory peduncle using microscopy techniques, revealing three layers, neuronal types, and associations between corpora amylacea and astrocytes.

Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

Neuronal migration depends on blood flow in the adult brain

The paper shows blood flow promotes neuronal migration in the adult brain by enhancing ghrelin signaling, which aids in olfactory function during food-seeking behavior.

A cross-species proteomic map reveals neoteny of human synapse development

This study creates a cross-species proteomic map of synapse development in human, macaque, and mouse neocortex, revealing slower human PSD maturation and its potential link to neoteny.

Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence

The paper identifies a previously unknown region in the mouse amygdala containing immature excitatory neurons that mature during adolescence and migrate into the endopiriform cortex, similar to human paralaminar neurons.

Persistent postnatal migration of interneurons into the human entorhinal cortex

This study shows that interneurons continue to migrate into the human entorhinal cortex postnatally, with distinct lineage contributions and maturation patterns identified using single-nuclei RNAseq.

Regulation of adult neurogenesis and neuronal differentiation by Neural Cell Adhesion Molecule 2 (NCAM2)

This study investigates the role of NCAM2 in regulating adult neurogenesis and neuronal differentiation by analyzing its effects on radial glial progenitors in the dentate gyrus and during corticogenesis.

Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenic lineages

The paper uses single-cell and single nucleus sequencing to identify two distinct adult neurogenic lineages in the mouse V-SVZ, marked by specific gene expression patterns.

Small Extracellular Vesicles Secreted by Region-specific Astrocytes Ameliorate the Mitochondrial Function in a Cellular Model of Parkinson's Disease

The paper investigates the neuroprotective effects of small extracellular vesicles from region-specific astrocytes in Parkinson's disease, showing they improve mitochondrial function.

Id4 is required for normal ependymal cell development

This study shows that Id4 is essential for ependymal cell development and function, as its deficiency leads to structural and functional abnormalities in the brain and spinal cord.

Enhanced tissue penetration of antibodies through pressurized immunohistochemistry

This paper introduces a method to enhance antibody penetration in thick tissues using pressurized immunohistochemistry, improving staining uniformity, intensity, and depth while reducing staining time for thin sections.