Structure-guided design of a targeted autoantibody degrader for neurologic disease
Marcell Zimanyi, Monica T. Dayao, Andoni I. Asencor, Sravani Kondapavulur, James Asaki, Krista M. McCutcheon, Cristina Dabaco, Aaron Bodansky, Charles S. Craik, Samuel J. Pleasure, Joseph L. DeRisi, Yifan Cheng, Michael R. Wilson, John V. Pluvinage
This paper designs a targeted autoantibody degrader to treat neurologic diseases by specifically clearing pathogenic autoantibodies while preserving the immune system.
bioRxiv · Feb 3, 2026 · PreprintNeuroscience