Author

John V. Pluvinage

University of California, San FranciscoORCID 0000-0002-9607-2783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aaron BodanskyiD· 1 shared Adam E. HandeliD· 1 shared Alexander J. DaviesiD· 1 shared Ana Luı́sa CarvalhoiD· 1 shared Ana Tereza Ribeiro de VasconcelosiD· 1 shared Andoni I. AsencoriD· 1 shared Andrew FoweriD· 1 shared Anna HarrisoniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperNeuroscience

Aaron BodanskyORCID

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3 papers

Recent·Most cited

Structure-guided design of a targeted autoantibody degrader for neurologic disease

Marcell Zimanyi, Monica T. Dayao, Andoni I. Asencor, Sravani Kondapavulur, James Asaki, Krista M. McCutcheon, Cristina Dabaco, Aaron Bodansky, Charles S. Craik, Samuel J. Pleasure, Joseph L. DeRisi, Yifan Cheng, Michael R. Wilson, John V. Pluvinage

This paper designs a targeted autoantibody degrader to treat neurologic diseases by specifically clearing pathogenic autoantibodies while preserving the immune system.

bioRxiv · Feb 3, 2026 · PreprintNeuroscience

Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis

Bo Sun, Dominique Fernandes, Anne‐Kathrin Kienzler, Sofija Paneva, Ruby Harrison, Sudarshini Ramanathan, Anna Harrison, Mateusz Makuch, Miriam L. Fichtner, Robert F. Donat, Deniz Akdeniz, Halwan Fuad Bayuangga, Min Gyu Im, Robyn Williams, Ana Tereza Ribeiro de Vasconcelos, , Sarosh R. Irani

bioRxiv · Jan 14, 2025 · PreprintImmunology

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

Julia Marschallinger, Tal Iram, Macy E. Zardeneta, Song Eun Lee, Benoit Lehallier, Michael Seamus Haney, John V. Pluvinage, Vidhu Mathur, Oliver Hahn, David W. Morgens, Justin Kim, Julia Tevini, Thomas Klaus Felder, Heimo Wolinski, Carolyn Ruth Bertozzi, , Tony Wyss‐Coray

The paper identifies lipid droplet-accumulating microglia (LAM) as a dysfunctional, pro-inflammatory state in aging brains, linked to neurodegeneration.

Nature Neuroscience · Jan 20, 2020Peer-reviewedNeuroscience