Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria
Camila Marques-da-Silva, Clyde Schmidt-Silva, Carson Bowers, Nana Appiah Essel Charles-Chess, Cristina Samuel, Justine C. Shiau, Eui‐Soon Park, Zhongyu Yuan, Bae-Hoon Kim, Dennis E. Kyle, John T. Harty, John D. MacMicking, Samarchith P. Kurup
This study identifies two IFN-I-driven hepatocyte antimicrobial programs that control liver-stage malaria by inducing GBPs and lysosomal defense mechanisms.
Cell Host & Microbe · Apr 1, 2025Peer-reviewedImmunology