Dennis E. Kyle

High throughput quantitative tracking of Plasmodium falciparum clonal blood stage parasite growth and applications for antimalarial drug discovery

This study develops qTRACE and AI tools to track Plasmodium falciparum parasite growth and drug effects, revealing dormancy recovery and resistance differences.

Virulence of Naegleria fowleri isolates varies significantly in the mouse model of primary amoebic meningoencephalitis

The paper tests virulence variation among Naegleria fowleri isolates using a mouse model and in vitro assays, finding significant differences in disease onset and mortality.

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria

This study identifies two IFN-I-driven hepatocyte antimicrobial programs that control liver-stage malaria by inducing GBPs and lysosomal defense mechanisms.

Secreted small RNAs of Naegleria fowleri as biomarkers for diagnosis of primary amoebic meningoencephalitis

This study identifies small RNAs from Naegleria fowleri that can be detected in liquid biopsies and serve as early diagnostic biomarkers for primary amoebic meningoencephalitis.

Extended blood stage sensitivity profiles of Plasmodium vivax to doxycycline and tafenoquine using Plasmodium cynomolgi as a model

The paper uses Plasmodium cynomolgi to determine the delayed antimalarial effects of doxycycline and tafenoquine on P. vivax, finding IC50 values for doxycycline and tafenoquine.

Naegleria fowleri: protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

The paper reports the structural determination of 19 N. fowleri proteins, identifying potential drug targets with structural differences from human homologs.

The transcriptome of Balamuthia mandrillaris trophozoites for structure-based drug design

The paper identifies 59 compounds that inhibit Balamuthia mandrillaris growth and reconstructs its transcriptome to determine potential molecular targets for drug development.

Mitochondrial heteroplasmy is responsible for Atovaquone drug resistance in Plasmodium falciparum

This study identifies mitochondrial heteroplasmy as the cause of Atovaquone resistance in Plasmodium falciparum, showing pre-existing Y268S alleles in the mitochondrial genome contribute to drug resistance.