Author

Cynthia X. Hou

John Radcliffe Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alvin Wei Tian NgiD· 1 shared Andrea PierangeliniiD· 1 shared Christopher J. LordiD· 1 shared Darragh Patrick O'BrieniD· 1 shared Dragomir B. KrasteviD· 1 shared Giuliana De GregoriisiD· 1 shared Gwendoline HoslettiD· 1 shared Ignacio TorrecillaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Alvin Wei Tian NgORCID

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1 paper

Recent·Most cited

Nucleophagy removes cytotoxic trapped PARP1

Gwendoline Hoslett, Sara Tribble, Pauline Lascaux, Stelios Koukouravas, Ignacio Torrecilla, Wei Song, Cynthia X. Hou, Xia Li, Martín González Fernández, Giuliana De Gregoriis, Rebecca A. Dagg, Darragh Patrick O'Brien, Andrea Pierangelini, Thibaud Martial, Alvin Wei Tian Ng, , Kristijan Ramadan

This study identifies nucleophagy as the mechanism by which trapped PARP1 is cleared, showing that inhibiting this process re-sensitizes PARPi-resistant cells to PARPi.

Nature Cell Biology · Jun 1, 2026Peer-reviewedCell Biology