Old mice fail to integrate a memory update into an existing hippocampal engram.
Chad A. Brunswick, Annie G. Defina, Trinity A. Wood, Derek J. Baldwin, Alexandria R. McKenna, Avery R. Sicher, Cyrus Marwaha, Dakota F. Brockway, Shoko Murakami, Gretchen C. Pifer, Chad W. Smies, Nicole A. Crowley, Janine L. Kwapis
This study shows that old mice have difficulty updating existing memories in the hippocampus, but re-engaging the original memory engram can improve this ability.
bioRxiv · Jun 26, 2026 · PreprintNeuroscience