Dakota F. Brockway

This study shows that old mice have difficulty updating existing memories in the hippocampus, but re-engaging the original memory engram can improve this ability.

This study shows that type-I nNOS neurons regulate neural and vascular dynamics in the brain by altering activity patterns and blood volume responses.

This study shows alcohol consumption disrupts somatostatin signaling in the prelimbic prefrontal cortex of mice, with potential implications for alcohol use disorder treatment.

This study shows that moderate alcohol consumption in mice affects prefrontal cortical signaling and neuronal excitability, potentially influencing Alzheimer's disease progression.

This study investigates the role of somatostatin peptide signaling in the prelimbic cortex, showing it dampens cortical circuits and promotes exploratory behavior through specific physiological and pharmacological mechanisms.

This study shows that adolescent binge drinking in mice causes lasting changes in cortical microcircuit function, specifically affecting SST neuron excitability and pyramidal neuron activity.

This study investigates the role of somatostatin neurons in the bed nucleus of the stria terminalis in binge drinking, finding sex-dependent effects in female mice.

This study shows that manipulating somatostatin neurons in the prelimbic cortex reduces binge alcohol consumption in both males and females.

This study investigates sex-specific neuroadaptations in somatostatin neurons during forced abstinence from alcohol, revealing altered intrinsic excitability and cFos expression in specific brain regions.

The paper develops an assay to induce and inhibit somatostatin release from prefrontal cortical neurons using optogenetic, transgenic, and biochemical methods.